diff --git a/v3/UNRELEASED_CHANGELOG.md b/v3/UNRELEASED_CHANGELOG.md
index 8e4648038..291c1fb1c 100644
--- a/v3/UNRELEASED_CHANGELOG.md
+++ b/v3/UNRELEASED_CHANGELOG.md
@@ -23,6 +23,7 @@ After processing, the content will be moved to the main changelog and this file
 
 ## Fixed
 <!-- Bug fixes -->
+- Fix fullscreen click-through on Windows when using `Frameless: true` with `BackgroundTypeTransparent` (#4408) by @leaanthony
 
 ## Deprecated
 <!-- Soon-to-be removed features -->
diff --git a/v3/pkg/application/webview_window_windows.go b/v3/pkg/application/webview_window_windows.go
index 434723fb4..1d8e1fbc4 100644
--- a/v3/pkg/application/webview_window_windows.go
+++ b/v3/pkg/application/webview_window_windows.go
@@ -890,10 +890,13 @@ func (w *windowsWebviewWindow) fullscreen() {
 		w32.GWL_STYLE,
 		w.previousWindowStyle & ^uint32(w32.WS_OVERLAPPEDWINDOW) | (w32.WS_POPUP|w32.WS_VISIBLE),
 	)
+	// Remove WS_EX_TRANSPARENT and WS_EX_LAYERED to ensure mouse events are captured in fullscreen mode.
+	// Both flags must be removed to fix click-through issues when Frameless + BackgroundTypeTransparent are used.
+	// See: https://github.com/wailsapp/wails/issues/4408
 	w32.SetWindowLong(
 		w.hwnd,
 		w32.GWL_EXSTYLE,
-		w.previousWindowExStyle & ^uint32(w32.WS_EX_DLGMODALFRAME),
+		w.previousWindowExStyle & ^uint32(w32.WS_EX_DLGMODALFRAME|w32.WS_EX_TRANSPARENT|w32.WS_EX_LAYERED),
 	)
 	w.isCurrentlyFullscreen = true
 	w32.SetWindowPos(w.hwnd, w32.HWND_TOP,