% Generated by roxygen2: do not edit by hand
% Please edit documentation in R/data.R
\docType{data}
\name{sepsis}
\alias{sepsis}
\title{Clinical Trial for Sepsis desease}
\format{470 patients and 13 variables. \describe{ \item{survival}{binary 
  outcome} \item{THERAPY}{1 for active treatment, 0 for control treatment} 
  \item{TIMFIRST}{Time from first sepsis-organ fail to start drug} 
  \item{AGE}{Patient age in years} \item{BLLPLAT}{Baseline local platelets} 
  \item{blSOFA}{Sum of baselin sofa (cardiovascular, hematology, 
  hepaticrenal, and respiration scores)} \item{BLLCREAT}{Base creatinine} 
  \item{ORGANNUM}{Number of baseline organ failures} 
  \item{PRAPACHE}{Pre-infusion apache-ii score} \item{BLGCS}{Base GLASGOW 
  coma scale score} \item{BLIL6}{Baseline serum IL-6 concentration} 
  \item{BLADL}{Baseline activity of daily living score} 
  \item{BLLBILI}{Baseline local bilirubin} }}
\source{
\url{http://biopharmnet.com/subgroup-analysis-software/}
}
\usage{
data(sepsis)
}
\description{
Simulated clinical trial with two groups treatment about sepsis desease. See 
details.
}
\details{
This dataset is taken from 
\href{http://biopharmnet.com/subgroup-analysis-software/}{SIDES
method}.

\code{Sepsis} contains simulated data on 470 subjects with a binary outcome 
survival, that stores survival status for patient after 28 days of treatment,
value of 1 for subjects who died after 28 days and 0 otherwise. There are 11 
covariates, listed below, all of which are numerical variables.

Note that contrary to the original dataset used in SIDES, missing values have
been imputed by random forest \code{(randomForest::rfImpute())}. See file 
data-raw/sepsis.R for more details.

True subgroup is \emph{PRAPACHE <= 26 & AGE <= 49.80}. \emph{NOTE:} This 
subgroup is defined with the \emph{lower} event rate (survival = 1) in
treatement arm.
}