aVirtualTwins/R/data.R

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1.8 KiB
R

#' Clinical Trial for Sepsis desease
#'
#' Simulated clinical trial with two groups treatment about sepsis desease. See
#' details.
#'
#' This dataset is taken from
#' \href{http://biopharmnet.com/subgroup-analysis-software/}{SIDES
#' method}.
#'
#' \code{Sepsis} contains simulated data on 470 subjects with a binary outcome
#' survival, that stores survival status for patient after 28 days of treatment,
#' value of 1 for subjects who died after 28 days and 0 otherwise. There are 11
#' covariates, listed below, all of which are numerical variables.
#'
#' Note that contrary to the original dataset used in SIDES, missing values have
#' been imputed by random forest \code{(randomForest::rfImpute())}. See file
#' data-raw/sepsis.R for more details.
#'
#' True subgroup is \emph{PRAPACHE <= 26 & AGE <= 49.80}. \emph{NOTE:} This
#' subgroup is defined with the \emph{lower} event rate (survival = 1) in
#' treatement arm.
#'
#' @format 470 patients and 13 variables. \describe{ \item{survival}{binary
#' outcome} \item{THERAPY}{1 for active treatment, 0 for control treatment}
#' \item{TIMFIRST}{Time from first sepsis-organ fail to start drug}
#' \item{AGE}{Patient age in years} \item{BLLPLAT}{Baseline local platelets}
#' \item{blSOFA}{Sum of baselin sofa (cardiovascular, hematology,
#' hepaticrenal, and respiration scores)} \item{BLLCREAT}{Base creatinine}
#' \item{ORGANNUM}{Number of baseline organ failures}
#' \item{PRAPACHE}{Pre-infusion apache-ii score} \item{BLGCS}{Base GLASGOW
#' coma scale score} \item{BLIL6}{Baseline serum IL-6 concentration}
#' \item{BLADL}{Baseline activity of daily living score}
#' \item{BLLBILI}{Baseline local bilirubin} }
#'
#' @usage data(sepsis)
#' @docType data
#' @source
#' \url{http://biopharmnet.com/subgroup-analysis-software/}
#'
#' @name sepsis
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