aVirtualTwins/R/data.R

#' Clinical Trial for Sepsis desease
#' 
#' Simulated clinical trial with two groups treatment about sepsis desease. See 
#' details.
#' 
#' This dataset is taken from 
#' \href{http://biopharmnet.com/subgroup-analysis-software/}{SIDES
#' method}.
#' 
#' \code{Sepsis} contains simulated data on 470 subjects with a binary outcome 
#' survival, that stores survival status for patient after 28 days of treatment,
#' value of 1 for subjects who died after 28 days and 0 otherwise. There are 11 
#' covariates, listed below, all of which are numerical variables.
#' 
#' Note that contrary to the original dataset used in SIDES, missing values have
#' been imputed by random forest \code{(randomForest::rfImpute())}. See file 
#' data-raw/sepsis.R for more details.
#' 
#' True subgroup is \emph{PRAPACHE <= 26 & AGE <= 49.80}. \emph{NOTE:} This 
#' subgroup is defined with the \emph{lower} event rate (survival = 1) in
#' treatement arm.
#' 
#' @format 470 patients and 13 variables. \describe{ \item{survival}{binary 
#'   outcome} \item{THERAPY}{1 for active treatment, 0 for control treatment} 
#'   \item{TIMFIRST}{Time from first sepsis-organ fail to start drug} 
#'   \item{AGE}{Patient age in years} \item{BLLPLAT}{Baseline local platelets} 
#'   \item{blSOFA}{Sum of baselin sofa (cardiovascular, hematology, 
#'   hepaticrenal, and respiration scores)} \item{BLLCREAT}{Base creatinine} 
#'   \item{ORGANNUM}{Number of baseline organ failures} 
#'   \item{PRAPACHE}{Pre-infusion apache-ii score} \item{BLGCS}{Base GLASGOW 
#'   coma scale score} \item{BLIL6}{Baseline serum IL-6 concentration} 
#'   \item{BLADL}{Baseline activity of daily living score} 
#'   \item{BLLBILI}{Baseline local bilirubin} }
#'   
#' @usage data(sepsis)
#' @docType data
#' @source 
#' \url{http://biopharmnet.com/subgroup-analysis-software/}
#' 
#' @name sepsis
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